Prof. Judy M. Delp, PhD, Florida State University U.S.A.

Circularity has assembled a Scientific Advisory Board (click for partial list) that includes domestic and international medical thought-leaders in the field of diabetic relief, wound healing, microvascular physiology, neurobiology, endocrinology, amputation prevention, vascular surgery, cardiovascular physiology, and others.

D'OXYVA has been reviewed, studied, and used at prestigious institutions around the world such as Penn State University, Florida State University, Valley Presbyterian Hospital, Hospital Kuala Lumpur, Airlangga University, Chulalongkorn University, University of Szeged, National Taipei University and others.

Improved oxygen-rich microcirculatory tissue perfusion is widely reported in published clinical research to improve physiological processes that lead to significant health benefits and clinical outcomes. These include, but are not limited to chronic, burn, trauma wound and tissue healing and repair, boosting athletic performance, stamina, sleep quality, fading spider and varicose veins while aiding in skin health, and much more.

D'OXYVA has recorded instant, outsized, and sustained improvements of the autonomic nervous system (ANS) in the brain, enhanced tissue perfusion and blood circulation in macro-, and microcirculation, chronic wound closure and balanced blood pressure in controlled human clinical trials (Phase I to III).

D'OXYVA is a Non-Invasive Transdermal Delivery (NTD), Non-Significant Risk (NSR) device, and Circularity Healthcare is conducting high-quality, cutting-edge clinical trials with leading institutions, researches, and health practitioners around the world to establish evidence for a wide variety of scientific and clinical outcomes with D'OXYVA. Please contact us to participate in Circularity's Center of Excellence (COE) program.

Featured White Paper:

Industry-Leading Noninvasive Transdermal Microcirculatory Technology for Rapid Closure of Complex Wounds with Significant Pain Relief

Human Clinical Trial Results Show Outsized Circulation & Clinical Outcomes

    D'OXYVA improved microcirculation (Skin Perfusion Pressure) in a statistically significant manner in 100% of subjects by about 15-100% from absolute baseline (median over 40%).

    Improvement in blood flow peaked uniformly within 1 hour after a single 5-minute delivery on their thumb, and subsequently lasted for over 4 hours.

    100% of enrolled subjects responded positively without adverse events after being monitored for a year after the study.

D'OXYVA Rogers Microcirculation Clinical Study Diabetic Foot Global Conference Poster Abstract

Read D'OXYVA Clinical Evidence

We will deliver clinical papers according to your chosen interests after you register via the below form.


(click & read)

Medical CO2 References

(partial list)

  • Blair DA, Glover WE, McArrdle L. The mechanism of the peripheral vasodilation following carbon dioxide inhalation in man. Clin Sci. 1960;19:407–423.

  • Matz H, Orion E, Wolf R. Balneotherapy in dermatology. Dermatol Ther. 2003;16:132–140. [PubMed]

  • Hartmann BR, Bassenge E, Pittler M. Effect of carbon dioxide-enriched water and fresh water on the cutaneous microcirculation and oxygen tension in the skin of the foot. Angiology. 1997;48:337–343. [PubMed]

  • Hartmann BR, Bassenge E, Hartmann M. Effects of serial percutaneous application of carbon dioxide in intermittent claudication: results of a controlled trial. Angiology. 1997;48:957–963. [PubMed]

  • Toriyama T, Kumada Y, Matsubara T, Murata A, Ogino A, et al. Effect of artificial carbon dioxide foot bathing on critical limb ischemia (Fontaine IV) in peripheral arterial disease patients. Int Angiol. 2002;21:367–73. [PubMed]

  • Brandi C, D'Aniello C, Grimaldi L, Bosi B, Dei I, et al. Carbon dioxide therapy in the treatment of localized adiposities: clinical study and histopathological correlations. Aesthetic Plast Surg. 2001;25:170–4. [PubMed]

  • Brandi C, D'Aniello C, Grimaldi L, Caiazzo E, Stanghellini E. Carbon dioxide therapy: effects on skin irregularity and its use as a complement to liposuction. Aesthetic Plast Surg. 2004;28:222–5. [PubMed]

  • Savin E, Bailliart O, Bonnin P, Bedu M, Cheynel J, et al. Vasomotor effects of transcutaneous CO2 in stage II peripheral occlusive arterial disease. Angiology. 1995;46:785–91. [PubMed]

  • Fabry R, Monnet P, Schmidt J, Lusson JR, Carpentier PH, et al. Clinical and microcirculatory effects of transcutaneous CO2 therapy in intermittent claudication. Randomized double-blind clinical trial with a parallel design. Vasa. 2009;38:213–24. [PubMed]

  • Schmidt J, Monnet P, Normand B, Fabry R. Microcirculatory and clinical effects of serial percutaneous application of carbon dioxide in primary and secondary Raynaud's phenomenon. Vasa. 2005;34:93–100. [PubMed]

  • Duling BR. Changes in microvascular diameter and oxygen tension induced by carbon dioxide. Circ Res. 1973;32:370–6. [PubMed]

  • Bohr C, Hasselbach K, Krogh A. Ueber emen in biologischen Bezuehung wichtigen Einfluss, den die Kohlen saurespannung des Blutes anf dessen Samerstoffbinding ubt. Arch. Physiol. 1904;16:402–412.

  • Riggs A. The nature and significance of the Bohr effect in mammalian hemoglobins. J. Gen. Physiol. 1960;43:737–752. [PMC free article] [PubMed]

  • Tyuma I. The Bohr effect and the Haldane effect in human hemoglobin. Jpn J Physiol. Jpn. J. Physiol. 1984;34:205–216.

  • Jensen FB. Red blood cell pH, the Bohr effect, and other oxygenation-linked phenomena in blood O2 and CO2 transport. Acta. Physiol. Scand. 2004;182:215–227. [PubMed]

  • Hashimoto M, Yamamoto N. Decrease in heart rates by artificial CO2 hot spring bathing is inhibited by beta1-adrenoceptor blockade in anesthetized rats. J. Appl. Physiol. 2004;96:226–232. [PubMed]

  • Yamamoto N, Hashimoto M. Spinal cord transection inhibits HR reduction in anesthetized rats immersed in an artificial CO2-hot spring bath. Int. J. Biometeorol. 2007;51:201–208. [PubMed]

  • Yamamoto N, Hashimoto M. Immersion in CO2-rich water containing NaCl diminishes blood pressure fluctuation in anesthetized rats. Int. J. Biometeorol. 2007;52:109–116. [PubMed]

  • Irie H, Tatsumi T, Takamiya M, Zen K, Takahashi T, et al. Carbon dioxide-rich water bathing enhances collateral blood flow in ischemic hindlimb via mobilization of endothelial progenitor cells and activation of NO-cGMP system. Circulation. 2005;111:1523–9. [PubMed]

  • Raymer GH, Green HJ, Ranney DA, Marsh GD, Thompson RT. Muscle metabolism and acid-base status during exercise in forearm work-related myalgia measured with 31P-MRS. J. Appl. Physiol. 2009;106:1198–1206. [PubMed]

  • Jöbsis FF. Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. Science. 1977;198:1264–1267. [PubMed]

  • Boushel R, Piantadosi CA. Near-infrared spectroscopy for monitoring muscle oxygenation. Acta. Physiol. Scand. 2000;168:615–622. [PubMed]

  • Koga S, Poole DC, Ferreira LF, Whipp BJ, Kondo N, et al. Spatial heterogeneity of quadriceps muscle deoxygenation kinetics during cycle exercise. J. Appl. Physiol. 2007;103:2049–2056. [PubMed]

  • Karalezli N, Ogun CO, Ogun TC, Yildirim S, Tuncay I. Wrist tourniquet: the most patient-friendly way of bloodless hand surgery. J. Trauma. 2007;62:750–754. [PubMed]

  • Miller SH, Lung RJ, Graham WP, Davis TS, Rusenas I. The acute effects of tourniquet ischemia on tissue and blood gas tensions in the primate limb. J. Hand. Surg. Am. 1978;3:11–20. [PubMed]

  • Mancini DM, Bolinger L, Li H, Kendrick K, Chance B, Wilson JR. Validation of near-infrared spectroscopy in humans. J. Appl. Physiol. 1994;77:2740–2747. [PubMed]

  • Chance B, Dait MT, Zhang C, Hamaoka T, Hagerman F. Hagerman, Recovery from exercise-induced desaturation in the quadriceps muscles of elite competitive rowers. Am. J. Physiol. 1992;262:C766–775. [PubMed]

  • Ganong WF. New York: Lange medical Books; 2005. Review of medical physiology. pp. 666–670.

  • Schenkman KA, Marble DR, Burns DH, Feigl EO. Myoglobin oxygen dissociation by multiwavelength spectroscopy. J. Appl. Physiol. 1997;82:86–92. [PubMed]

  • Hilpert P, Fleischmann RG, Kempe D, Bartels H. The Bohr effect related to blood and erythrocyte pH. Am. J. Physiol. 1963;205:337–340. [PubMed]

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