What it does


D'OXYVA® (deoxyhemoglobin vasodilator) is the only fully non-invasive, non-irritating, non-opioid, and completely painless, transdermal (over the skin) microcirculatory solution with industry-leading clinical research results that does not break the skin's barrier.

In short, based on current leading neurology, immunology, microvascular, and cellular oxygenation science, D'OXYVA is leading the field by quickly targeting to:

Significantly lower the risk of diabetes and cardiovascular complications

Provide complete healing of difficult wounds together with major pain relief and improved quality of life:

  • Detoxify the skin and body
  • Improve sleep
  • Stamina and skin health
  • Reduce inflammation
  • And much more for all kinds of people


Highlighted reviews

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"My heartfelt thank you to Circularity management for their support before and after my heart attack. I firmly believe the collateral capillaries that have formed on my heart, bypassing the damage, is a direct result of my using the Circularity system. I'm very happy to report an increase from 15% to an estimated 30% in the injection fraction number( I believe that is the correct name) that has occurred since I left the hospital. The generous gift of treatment cartridges has allowed me to increase my daily usage to 2-3 times per day and the cardiologist now says I may be a candidate for bypass surgery. I will keep the company informed of my progress. Again THANK YOU CIRCULARITY for making it possible for me to write this letter." - Loyd Rhodes, Sacramento, CA United States

"I have found that after only two weeks of using the D'OXYVA system daily that my metabolism has increased and is helping me to lose weight. My sex drive has increased and I am sleeping better throughout the night." - Judy Trocha from Pollock Pines, CA United States


How it works


D'OXYVA's soft vapor solution with FDA-cleared medical CO2 readily dissolves in a molecular form in the skin to increase skin perfusion pressure, microcirculation.

It is non-electrical, handheld, painless, fast, and easy to use with no adverse side effects, according to years of user feedback and the results of past clinical trials with D'OXYVA.

It is an affordable, stand alone and adjunct application locally and all over the body. Taking D'OXYVA is easy; hold it against your skin surface for 5 minutes total, like comfortably inserting your thumb or anywhere you are hurt.



Increased oxygen-rich microcirculatory tissue perfusion is widely reported in published clinical research to improve physiological processes including but not limited to wound, tissue healing and repair, athletic performance, stamina, sleep quality, skin health, and much more.

D'OXYVA has recorded instant, outsized, and sustained improvements of the autonomic nervous system (ANS) in the brain leading to major tissue perfusion, blood circulation in macro-, and microcirculation enhancement in controlled human clinical trials (Phase I to III). These benefits result in significant improvements of essential physiological processes and clinical outcomes.



Medical CO2 gas is a widely accepted so-called gasotransmitter acting as a natural vasodilator amongst other beneficial critical signaling funtions when delivered by D'OXYVA's patented and patent-pending process.

D'OXYVA delivers the highest possible concentration of CO2 and has been clinically studied to significantly increase lasting blood flow volume in the microcirculatory system.

In addition, increased microcirculation with CO2 is widely known to increase the perfusion of oxygen.




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